American Society of Clinical Oncology (ASCO) has issued a new guideline for antimicrobial prophylaxis and outpatient management of fever and neutropenia
An Expert Panel set up by the American Society of Clinical Oncology (ASCO) has developed new guidelines based on extracted data and informal consensus for antimicrobial prophylaxis and outpatient management of fever and neutropenia in adults treated for malignancy.
Antibacterial and antifungal prophylaxis is only recommended for patients expected to have <100 neutrophils/microliter for >7days.
An oral fluoroquinolone, such as levofloxacin or ciprofloxacin, plus amoxicillin/clavulanate (or plus clindamycin if the patient is penicillin allergic) is recommended as empirical treatment unless fluoroquinolone prophylaxis was given before a fever developed.
J Clin Oncol. 2013 Feb 20;31(6):794-810. doi: 10.1200/JCO.2012.45.8661. Epub 2013 Jan 14.
Source : http://www.ncbi.nlm.nih.gov/pubmed/23319691?dopt=Abstract