Update of the Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections
These 2005 guidelines have been updated by a panel of national experts of the Infectious Diseases Society of America. The experts were from major medical facilities across the USA and the guidelines cover the diagnosis and treatment of a variety of SSTIs and highlight the importance of clinical skills in the rapid diagnosis of SSTIs, identifying the pathogens involved and selecting effective treatments as quickly as possible. The publication presents a detailed account of the methods, background, and evidence summaries in support each of the recommendations.
Regarding fluoroquinolone antibiotics, in the case of surgery of the intestinal or genitourinary tract, the guidelines recommend a combination of levofloxacin 750mg IV every 24h + metronidazole 500mg every 8h IV.
For surgery of the axilla or perineum, levofloxacin 750mg every 24h IV or PO + metronidazole 500mg every 8h IV is recommended.
In the case of infections following animal or human bites, one of the few fluoroquinolones recommended is levofloxacin 750mg daily, either IV or orally. Also, one of the few recommended fluoroquinolones for the treatment of cutaneous anthrax in cases involving bioterrorism is levofloxacin 500mg IV or PO.
Clin Infect Dis. 2014 Jul 15;59(2):e10-52. doi: 10.1093/cid/ciu296. Epub 2014 Jun 18.
Source : http://www.ncbi.nlm.nih.gov/pubmed/24947530?dopt=Abstract