Answer 10: Effect of High-Dose therapy on Compliance

20 June, 2018



While both doses are given as once daily schedules, the 750 mg dose course lasts only 5 days, which is shorter than the usual course of 7-14 days. Studies of anti-infective therapy have shown that compliance is improved if a reduced number of pills are required per day and length of treatment is reduced (14, 15). Better compliance has also been shown to be associated with better clinical outcomes. Other factors that reduce compliance include adverse events. Thus, shorter course therapy should enhance patient convenience, potentially resulting in increased efficacy and avoiding the costs of retreatment due to treatment failure.