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Age-linked variations in UTI pathogens and antibiotic resistance patterns may guide empirical antimicrobial treatment

Urinary tract infections (UTIs) are one of the most common reasons for hospital visits worldwide and are associated with significant economic burden.1-3 In the United States alone, an estimated 2.8...

Urinary tract infections (UTIs) are one of the most common reasons for hospital visits worldwide and are associated with significant economic burden.1-3 In the United States alone, an estimated 2.8...

Colchicine does not prevent mechanical ventilation or reduce mortality risk in COVID-19 hospitalisations

Mortality rates among COVID-19-linked hospitalisations stand at a reported 17.1%,1 which is markedly above the global COVID-19 mortality rate of 1.3%, as calculated based on the current global data on...

Mortality rates among COVID-19-linked hospitalisations stand at a reported 17.1%,1 which is markedly above the global COVID-19 mortality rate of 1.3%, as calculated based on the current global data on...

Helicobacter pylori infections: A review of the current standard of care

16 February, 2022

In 2015, approximately 4.4 billion Helicobacter pylori infections were reported worldwide.1 Prevalence of H. pylori infections varies across countries, with more industrialised countries showing a plateau or decline in infection...

In 2015, approximately 4.4 billion Helicobacter pylori infections were reported worldwide.1 Prevalence of H. pylori infections varies across countries, with more industrialised countries showing a plateau or decline in infection...

A combination of prior infection and vaccination confers the strongest immune response against COVID-19 variants

12 January, 2022

Variants of SARS-CoV-2, the virus causing COVID-19, are constantly emerging and will likely continue to, driven by community carriers.1 Immunity to the virus is attained through vaccination or prior infection,...

Variants of SARS-CoV-2, the virus causing COVID-19, are constantly emerging and will likely continue to, driven by community carriers.1 Immunity to the virus is attained through vaccination or prior infection,...

Antimicrobial treatment of urinary tract infection with temocillin shows reduced selection for resistant gut bacteria compared with cefotaxime

14 December, 2021

Cefotaxime, a broad-spectrum antibiotic, also effective against certain multiresistant strains, is currently used to treat febrile urinary tract infections (UTIs).1 Failure of cefotaxime (and other third-generation cephalosporins) due to reduced...

Cefotaxime, a broad-spectrum antibiotic, also effective against certain multiresistant strains, is currently used to treat febrile urinary tract infections (UTIs).1 Failure of cefotaxime (and other third-generation cephalosporins) due to reduced...

Localised vancomycin delivery via microneedle arrays reduces methicillin-resistant Staphylococcus aureus growth on skin

12 November, 2021

Skin and soft-tissue infections (SSTI) are a common type of bacterial infection, making up almost 10% of annual hospitalisations.1 Staphylococcus aureus is the causative agent in most cases of SSTIs,...

Skin and soft-tissue infections (SSTI) are a common type of bacterial infection, making up almost 10% of annual hospitalisations.1 Staphylococcus aureus is the causative agent in most cases of SSTIs,...

High viral abundance in lungs and low immune response to SARS-CoV-2 predicts mortality

19 October, 2021

Factors associated with COVID-19 mortality include age, obesity, the need for mechanical ventilation following respiratory failure, and certain comorbidities.1,2 Recent research has also suggested that features of the lung microbiome...

Factors associated with COVID-19 mortality include age, obesity, the need for mechanical ventilation following respiratory failure, and certain comorbidities.1,2 Recent research has also suggested that features of the lung microbiome...

Highly antimicrobial-resistant bacteria increase severity and mortality in patients with intensive care unit-acquired pneumonia

16 September, 2021

Antimicrobial resistance is a growing global health concern. The spread of antimicrobial resistant (AMR) pathogens means that the treatment of common infections is becoming increasingly complicated.1 Despite this, there remains...

Antimicrobial resistance is a growing global health concern. The spread of antimicrobial resistant (AMR) pathogens means that the treatment of common infections is becoming increasingly complicated.1 Despite this, there remains...

COVID-19 post-infection immunity persists for at least 9 months

23 August, 2021

In most patients who have been infected with severe acute respiratory syndrome (SARS-CoV-2), the virus that causes COVID-19, antibody responses can be detected in their sera 10–15 days from the...

In most patients who have been infected with severe acute respiratory syndrome (SARS-CoV-2), the virus that causes COVID-19, antibody responses can be detected in their sera 10–15 days from the...

Tofacitinib lowered mortality risk in patients hospitalised with COVID-19 pneumonia

Disease progression in COVID-19 is associated with an impaired immune response, which leads to a cytokine release syndrome, or hyperinflammatory state.1 Treatment or management of this response could improve disease...

Disease progression in COVID-19 is associated with an impaired immune response, which leads to a cytokine release syndrome, or hyperinflammatory state.1 Treatment or management of this response could improve disease...

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