Question 3

Do the PK/PD features of levofloxacin change when given orally?

This is another important advantage associated with levofloxacin, and the fluoroquinolones in general. Levofloxacin possesses exceptional bioavailability, making it possible to achieve remarkably similar concentrations when given orally or by intravenous administration. In contrast, ciprofloxacin usually requires a higher dose when given orally.