Pharmacokinetic/Pharmacodynamic Breakpoints: Time to Consider New Parameters of Antimicrobial Efficacy | Infection Update

Pharmacokinetic/Pharmacodynamic Breakpoints: Time to Consider New Parameters of Antimicrobial Efficacy

21 June, 2018

drusana

Pharmacokinetic/Pharmacodynamic Breakpoints: Time to Consider New Parameters of Antimicrobial Efficacy

George L. Drusano, MD

Question

Q 1.		Pharmacokinetic features: selection of therapeutic drugs
Q 2.		Pharmacodynamic parameters: a new paradigm?
Q 3.		Peak/MIC or AUC/MIC: which is more important?
Q 4.		AUC/MIC and peak/MIC: Gram-positives and -negatives
Q 5.		AUC/MIC and peak/MIC: mild versus severe disease
Q 6.		Serum antibiotic concentrations and drug efficacy
Q 7.		Pharmacodynamic indices for modifying dosage and regimen
Q 8.		Target ratios: important for preventing resistance?
Q 9.		Target AUC/MIC ratios and resistance
Q10.		Mathematical modeling techniques
Q11.		Pharmacodynamic parameters and adverse drug reactions
Q12.		Post-antibiotic effect: fluoroquinolones
Q13.		Future clinical developments: pharmacodynamic parameters

LATEST TOPICS