Question 6
How has the emergence of drug-resistant pathogens changed the empiric therapy of URTIs, such as rhinosinusitis? Would you agree that relatively high rates of resistance to H. influenzae and S. pneumoniae have changed prescribing habits from ampicillin or amoxicillin to agents that were once considered second- or third-line therapies (fluoroquinolones, second-generation cephalosporins, -lactams, or newer macrolides)?